Pharmaceutical Research Center, Second Affiliated Hospital, Dalian Medical University, Dalian, China; Puensum Genetech Institute, Wuhan, China; Department of Microbiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China. Puensum Genetech Institute, Wuhan, China. Ambulatory Chemotherapy Center, Department of Medical Oncology, Dalian University Affiliated Xinhua Hospital, Dalian, China. Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China; Department of Obstetrics and Gynecology, Columbia University, New York, NY, USA. Pharmaceutical Research Center, Second Affiliated Hospital, Dalian Medical University, Dalian, China. Department of Microbiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China. Department of Microbiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China. Electronic address: qiulongy1988@163.com. Pharmaceutical Research Center, Second Affiliated Hospital, Dalian Medical University, Dalian, China. Electronic address: maxc1978@163.com.